35 years old female with fever and ulcers over body


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I have been given this case to solve in an attempt to understand the topic of " patient clinical data analysis" to develop my competency in reading and comprehending clinical data including history, clinical findings, investigations and come up with diagnosis and treatment plan.


35 year old female, farmer by occupation resident of aakaram came to the general medicine OPD with chief complaints of fever and ulcers since 6 days

HOPI:


The patient was apparently asymptomatic  until 6 days back she then developed low grade fever  sudden in onset , continuous in nature relived on medication h/0 of malaise not associated with chills,rigors,sweating, dizziness, fatigue and body pains, nausea, vomiting

Second day after onset of fever she went to her paddy farm for work in the early morning and injured her left toe while spraying fertilizer . From third day she noticed progressive painful lesions appearing on both lower limbs and upper limbs chest and neck . No loss of sensation, itching, joint pains.


Difficulty in swallowing and burning sensation in the mouth post consumption of food due to small ulcers in the mouth and not associated with any blood discharge from the mouth.

No complaints of headache, burning micturition, giddiness, chest pain, shortness of breath, palpitations, cough ,insomnia, loose stools, loss of appetite. 


History of usage of semecarpus anacardium for one day. Following which she went a local practitioner and was prescribed an tablet containing  deflazocort 6mg for five days itraconazole ,tofloxacin, orividazole, clobetasol propionate, and megaheal ointment for five days.




PAST HISTORY:


NO h/o hypertension, diabetes,asthma, epilepsy, tuberculosis


No known allergy 


TREATMENT HISTORY : History of psoriasis vulgaris from 2 years for which she used tab methotrexate 7.5mg BD for one month and capsule itraconazole.


PERSONAL HISTORY:


Appetite: decreased


Diet:mixed


Sleep: adequate


Bowel and bladder are regular


Patient denies of any addictions

Daily activities:


wakes up at 5 am does household chores till 9am and have food for Breakfast and goes to farm and comes back by evening 5pm, cooks food, have dinner and go to bed by 9pm. 


FAMILY HISTORY:


no history of similar complaints within the family


General examination


Pallor: absent

Icterus:absent

Clubbing: absent

Cyanosis: absent

Lymphadenopathy: absent

Edema: absent


SKIN :hyperpigmented macules and ulceration All over the body 


Local rise in temperature present 

On 3/2/2023

Vitals:


Temp: afebrile


BP : 110/70


Heart rate : 110 bpm


Resp Rate 16cycles/min


SYSTEMIC EXAMINATION 


RESPIRATORY SYSTEM 


I: Chest bilaterally symmetrical, all quadrants


moves equally with respiration


P: Trachea central, chest expansion normal


P: Resonant


A: B/l air entry, no added sounds 

CVS EXAMINATION:


I: No precordial bulge. Apical impulse


visible


P: Apical impulse, No palpebral pulsation.


A: S1 S2, No murmur




ABDOMINAL EXAMINATION:


Abdomen is soft and non tender


No organomegaly


No shifting dullness


No fluid thrill


Bowel sounds heard

CNS 

No focal neurological deficits 


ORAL CAVITY EXAMINATION: 

Few whithish plaques noted over the oral mucosa 


NOSE EXAMINATION:

Mild anterior DNS to left 


Investigations 

Fever chart 



Blood urea -30mg/dl
Serum creatinine -0.8mg/dl
Serum electrolytes 
Liver function tests 
Esr -80mm in 1 hour
Cue
Cbp PANCYTOPENIA 

Ultra sound
2d echoe 

Ecg 

Differential diagnosis 
Methotrexate toxicity causing PANCYTOPENIA and ORAL ulcers
Allergic contact dermatitis secondary to semicarpus anacardium 

TREATMENT: 

TAB. AUGMENTIN 625mg TID
TAB DOLO 650mg PO/BD
FUDIC CREAM
TAB. FOLINIC ACID 15 mg BD
ZYTEE GEL  

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